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1. Showrunner/Director: Darren Aronofsky
A huge comic book fan, Aronofsky has been linked to various comic book adaptations in the past, including Batman and Wolverine. He's created comic book tie-ins for his movies The Fountain and Noah. But he's not the director for a straight forward superhero movie. His worlds are too dirty, too real for that. He's a science fiction director who can stay within budget. Which is needed for this project.
2. Antagonist: Edward Norton as The Smiler
The Smiler is a two-faced bastard. Friendly and smiling in one moment, with an evil grin in the next. His image is that of the last honest politician, a loving family man. But in reality, he's a scheming manipulator who lets his family and friends die in accidents whenever it benefits his political career. Norton has built his whole career on split personalities. Primal Fear, Fight Club, Incredible Hulk... There's nobody better for this role than him.
3. Protagonist: John C. McGinley as Spider Jerusalem
He's a cynical journalist armed with a laptop and a bowel disuptor. He's the only man smart enough to see through the Smiler's plans. He is the only one powerful enough to take the fucker down.
Who else but John C. McGinley? He looks the part, he played a cynical but highly intelligent man for years on Scrubs, and he works on a tv budget.
4. Love Interest: Rachael Leigh Cook as Yelena Rossini
As the niece of Spider's editor, she starts out as his clean, almost shy assistant. But Spider's influence on her makes her smarter - and more depraved. By the time he's done with her, she's turned into him, cigarettes, tattoos and all.
Rachael Leigh Cook is versatile and pretty enough to play both sides.
5. Supporting Character: Lelee Sobieski as Channon Yarrow.
At the beginning of Transmetropolitan, she is a stripper. She assists Spider on his first mission back in the city - and becomes his assistant and bodyguard afterwards. Leelee Sobieski has the looks, but can kick ass if necessary.
6: Storyline: Transmetropolitan #1-60
William Gibson meets Frost/Nixon.
A cyberpunk tale in a not-too-distant future, about the last journalist with the balls to mess with the President. Warren Ellis' masterpiece, and one of Vertigo's most successful books. Mandatory reading. And it would work nicely as an AMC or HBO series. Five seasons, twelve episodes each. Perfect.[/QUOTE]
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